1. The Abstract of Aframomum Melegueta

The Aframomum Melegueta, native to West Africa, has a cardamom smell and a peppery flavor. It was widely used as a substitute when pepper was scarce in Europe in the 13th century, and was called the “seed of heaven” because it was considered a favor from heaven.

Aframomum Melegueta has different names such as grains of paradise, Atare (in Yoruba), chitta (Hausa), or Guinea pepper, is one seed with many healing power and its benefits to mankind seems endless.

Aframomum melegueta (Grains of Paradise) has being in used for the treatment of infectious diseases such as urinary tract infections caused by Escherichia coli, Klebsiella pneumoniae, Enterococcus faecalis, Staphylococcus saprophyticus, Proteus mirabilis, methicillinresistant Staphylococcus aureus, Salmonella spp, and Shigella spp. It shows some promise in fat-mass control at doses possibly consumable in food products and medicinal concoction.

2.Distribution Area

Aframomum Melegueta（Paradise Pepper）, whose real name is African Cardamom, also known as Peppercorn, Guinea Pepper, Melegueta Pepper, Paradise Pepper, or Alligator Pepper, is a perennial herb of the Zingiberaceae family. Native to coastal swamps of West Africa. Opens purple, trumpet-shaped flowers, bears 5-7 cm long pods and contains reddish-brown seeds. Peppery, also because it became an early pepper substitute. Now it is only common in internal consumption in Africa. It is another Silk Road spice that has disappeared from modern Eurasian cuisine, but is still used in parts of West and North Africa, and is an important cash crop in parts of Ethiopia. African cardamom, which is native to the coastal areas of western Africa, seems to have been used near modern Ghana at first and was later shipped to some port areas in eastern Africa or along the Mediterranean coast to trade through the Silk Road. The spice, which was all the rage in European cooking during the early Renaissance, slowly faded from the table by the eighteenth century and then disappeared from European markets, replaced by cardamom and other spices exported from Asia around the world.

3. Introduction of 6-Paradol

Paradol, a non-pungent metabolite of shogaol by enzymatic reduction, is known to possess anti-inflammatory activities. Current in vitro findings demonstrates that the inhibitory properties of 6-paradol in treating neuroinflammation in microglia correlates to the in vivo therapeutic potential for cerebral ischemia. 6-paradol’s neuroprotective efficacy in cerebral ischemia also has its potential use in the treatment of other CNS disorders in which neuroinflammation is a pathological feature. In addition, if 6-paradol is shown to be effective in other CNS disorders, its non-pungent property has the advantage of fewer side effects on the stomach, which means it can be taken long-term, unlike that of ginger or ginger’s components likely 6-shogaol.

6-paradol is a highly potent antimalarial and a major component of Z.o. secondary metabolite pool.

6-Paradol (IUPAC name [1-(4-hydroxy-3-methoxyphenyl) decan-3-one]) is a pungent phenolic compound found in plants of the Zingiberaceae family, such as ginger and grains of paradise (Aframomum melegueta or alligator pepper). As mentioned elsewhere, a few studies have reported the antioxidant, anti-inflammatory, cytotoxic, anti-hyperlipidaemic, hypoglycaemic, and antitumour activities of different paradol compounds in various animal models.