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In a recent study published in the journal Pharmaceutics, researchers determined the antimicrobial effectiveness of an herbal formula called FRO against acne pathogenesis.
Antimicrobial evaluation and in vitro analysis showed that FRO has significant antibacterial and anti-inflammatory effects against Dermatobacillus Acnes (CA), a bacterium that causes acne. These results demonstrate its safe and natural use in the cosmetic treatment of acne, supporting the use of non-toxic and cost-effective alternatives to current acne medications.
Study: Efficacy of FRO in the pathogenesis of acne vulgaris. Image credit: Steve Jungs/Shutterstock.com
Acne vulgaris, commonly known as pimples, is a common skin condition caused by clogged hair follicles with sebum and dead skin cells. Acne affects more than 80 percent of teenagers and, although not fatal, can cause mental distress and, in severe cases, permanent skin pigmentation and scarring.
Acne results from an interaction of genetic and environmental factors, often caused by the hormonal changes that accompany puberty during puberty. These hormonal imbalances increase sebum production and increase insulin growth factor 1 (IGF-1) and dihydrotestosterone (DHT) activity.
Increased sebum secretion is considered the first stage in the development of acne, since hair follicles saturated with sebum contain a large number of microorganisms such as SA. SA is a natural commensal substance of the skin; however, increased proliferation of its phylotype IA1 causes inflammation and pigmentation of hair follicles with externally visible papules.
There are various cosmetic treatments for acne, such as retinoids and topical microbial agents, used in combination with chemical peels, laser/light therapy, and hormonal agents. However, these treatments are relatively expensive and are associated with adverse side effects.
Previous studies have explored herbal extracts as a cost-effective natural alternative to these treatments. As an alternative, Rhus vulgaris (RV) extracts have been studied. However, its use is limited by urushiol, a key allergenic component of this tree.
FRO is a herbal formula containing fermented extracts of RV (FRV) and Japanese mangosteen (OJ) in a 1:1 ratio. The effectiveness of the formula has been tested using in vitro assays and antimicrobial properties.
The FRO mixture was first characterized using high performance liquid chromatography (HPLC) to isolate, identify and quantify its components. The mixture was further analyzed for total phenolic content (TPC) to identify compounds most likely to have antimicrobial properties.
Preliminary in vitro antimicrobial assay by assessing disc diffusion sensitivity. First, CA (phylotype IA1) was uniformly cultured on an agar plate on which a 10 mm diameter FRO-impregnated filter paper disk was placed. Antimicrobial activity was assessed by measuring the size of the inhibitory region.
The effectiveness of FRO on CA-induced sebum production and DHT-associated androgen surges was assessed using Oil Red staining and Western blot analysis, respectively. FRO was subsequently tested for its ability to neutralize the effects of reactive oxygen species (ROS), which are responsible for acne-associated hyperpigmentation and post-surgical scars, using a 2′,7′-dichlorofluorescein diacetate (DCF-DA) probe. cause.
The results of the disk diffusion experiment showed that 20 μL of FRO successfully inhibited CA growth and produced an apparent inhibition zone of 13 mm at a concentration of 100 mg/mL. FRO significantly suppresses the increase in sebum secretion caused by SA, thereby slowing down or reversing the occurrence of acne.
FRO has been found to be rich in phenolic compounds including gallic acid, kaempferol, quercetin and fisetin. Total phenolic compound (TPC) concentration averaged 118.2 mg gallic acid equivalents (GAE) per gram FRO.
FRO significantly reduced cellular inflammation caused by SA-induced ROS and cytokine release. Long-term reduction in ROS production may reduce hyperpigmentation and scarring.
Although dermatological treatments for acne exist, they are often expensive and can have many unwanted side effects.
The results show that FRO has antibacterial properties against CA (acne-causing bacteria), thereby demonstrating that FRO is a natural, non-toxic and cost-effective alternative to traditional acne treatments. FRO also reduces sebum production and hormone expression in vitro, demonstrating its effectiveness in treating and preventing acne flare-ups.
Previous FRO clinical trials showed that people using FRO’s advanced toner and lotion experienced significant improvements in skin elasticity and moisture levels compared to the control group after just six weeks. Although this study did not evaluate acne under controlled in vitro conditions, the current results support their findings.
Taken together, these results support the future use of FRO in cosmetic treatments, including acne treatment and improving overall skin health.
This article was edited on June 9, 2023 to replace the main image with a more appropriate one.
Posted in: Medical Science News | Medical Research News | Disease News | Pharmaceutical news
Tags: acne, adolescents, androgens, anti-inflammatory, cells, chromatography, cytokines, dihydrotestosterone, effectiveness, fermentation, genetics, growth factors, hair, hormones, hyperpigmentation, in vitro, inflammation, insulin, phototherapy, liquid chromatography, oxygen, proliferation, quercetin , retinoids, skin, skin cells, skin pigmentation, Western blot
Hugo Francisco de Souza is a science writer based in Bangalore, Karnataka, India. His academic interests are in the fields of biogeography, evolutionary biology and herpetology. He is currently working on his doctoral dissertation. from the Center for Environmental Sciences at the Indian Institute of Science, where he studies the origin, distribution and speciation of wetland snakes. Hugo was awarded a DST-INSPIRE Fellowship for his doctoral research and a Gold Medal from the Pondicherry University for his academic achievements during his Master’s studies. His research has been published in high-impact peer-reviewed journals including PLOS Neglected Tropical Diseases and Systems Biology. When he’s not working and writing, Hugo binges on tons of anime and comics, writes and composes music on the bass guitar, shreds tracks on the MTB, plays video games (he prefers the word “game”), or tinkers with just about anything. technologies.
Francisco de Souza, Hugo. (July 9, 2023). A unique blend of plant extracts provides powerful anti-acne benefits. News – Medical. Retrieved September 11, 2023, from https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Francisco de Souza, Hugo. “A unique blend of plant extracts with powerful anti-acne properties.” News – Medical. September 11, 2023 .
Francisco de Souza, Hugo. “A unique blend of plant extracts with powerful anti-acne properties.” News – Medical. https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx. (Accessed September 11, 2023).
Francisco de Souza, Hugo. 2023. A unique blend of plant extracts with powerful anti-acne properties. News Medical, accessed September 11, 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
The photographs used in this “summary” are not related to this study and are completely misleading in suggesting that the study involved testing on humans. It should be removed immediately.
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